Androgen deficiency

Idiopathic intracranial hypertension linked to androgen deficiency

Idiopathic intracranial hypertension (IIH), also known as pseudotumor cerebri, has been noted with a number of patients. IIH can cause blurred vision, headaches, including migraines, and vertigo. These symptoms correlate with patients from all groups. Tinnitus, which is also common in all groups, is a major manifestation of intracranial hypertension. IIH may also cause nausea/vomiting, lethargy and tiredness .

An evaluation of 101 IIH cases found that symptoms included neck stiffness, distal extremity paresthesias (tingling and numbness in extremities), joint pains, lower back pain and gait “ataxia” .

Idiopathic intracranial hypertension has been linked to androgen deficiency. A deregulation of AR signaling in patients could therefore explain IIH and related symptoms. Of further interest, the main drug used in management of IIH, acetazolamide, showed androgen agonistic activity, giving further support to the notion that IIH is an androgen related disorder.