Accutane and Thyroid Gland Shrinkage

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    A newly published study of 104 acne patients, which appears to have been part of the Turkish science and technology bureau’s investigation of Accutane/Isotretinoin, shows significantly decreased thyroid gland volume, decreased levels of thyroid hormones, and increased levels of thyroid stimulating hormone (TSH).
    The full article here:

    They also discuss the results of previous related studies over the years:


    It has long been known that high doses of vitamin A can interfere with the effects of thyroid hormone metabolism. Sadhu and Brody demonstrated a 10% decrease in oxygen consumption, a depressed metabolic rate and, interestingly, a 35% decrease of thyroid weight in euthyroid rats given high doses of vitamin A.[8]The effect of vitamin A and retinoids on the hypothalamic-pituitary-thyroid axis has been well recognized but poorly understood.[9],[10]

    Retinoids can affect cell growth, differentiation, function and metabolism via two groups of nuclear hormone receptors: retinoic acid receptors and retinoid X receptors. These receptors also mediate the activity of steroid and thyroid hormones.[11]


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